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The Big Bang Theory is centered on five characters living in Pasadena, California: roommates Leonard Hofstadter and Sheldon Cooper; Penny, a waitress and aspiring actress who lives across the hall; and Leonard and Sheldon's equally geeky and socially awkward friends and co-workers, mechanical engineer Howard Wolowitz and astrophysicist Raj Koothrappali.
The geekiness and intellect of the four guys is contrasted beautifully for comic effect with Penny's social skills and common sense and sarcastic humor!